Gums & Joints

a FP7 EU collaborative project, with an aim to investigate protein citrullination as a link between periodontal disease and rheumatoid arthritis main page

Media Coverage:

Publications:

Valnickova Z, Sanglas L, Arolas JL, Petersen SV, Schar C, Otzen D, Aviles FX, Gomis-Rüth FX, Enghild JJ. Flexibility of the thrombin-activatable fibrinolysis inhibitor pro-domain enables productive binding of protein substrates. J Biol Chem. 2010 Dec 3;285(49):38243-50. www.ncbi.nlm.nih.gov/pubmed/20880845
Goulas T, Arolas JL, Gomis-Rüth FX . Structure, function and latency regulation of a bacterial enterotoxin potentially derived from a mammalian adamalysin/ADAM xenolog. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1856-61.
www.ncbi.nlm.nih.gov/pubmed/21233422
Tanco S, Arolas JL., Guevara T., Lorenzo J., Avilés FX., and Gomis-Rüth FX. Structure-Function Analysis of the Short Splicing Variant Carboxypeptidase Encoded by Drosophila melanogaster silver. J Mol Biol. 2010 Aug 20;401(3):465-77.
www.ncbi.nlm.nih.gov/pubmed/20600119
Cerdà-Costa N, Guevara T, Karim AY, Ksiazek M, Nguyen KA, Arolas JL, Potempa J, Gomis-Rüth FX. The structure of the catalytic domain of Tannerella forsythia karilysin reveals it is a bacterial xenologue of animal matrix metalloproteinases. Mol Microbiol. 2011 Jan;79(1):119-32. www.ncbi.nlm.nih.gov/pubmed/21166898
Guentsch A, Kramesberger M, Sroka A, Pfister W, Potempa J, Eick S. Comparison of Gingival Crevicular Fluid Sampling Methods in Patients With Severe Chronic Periodontitis. J Periodontol. 2011 Jan 14.
www.ncbi.nlm.nih.gov/pubmed/21235330
Golda A, Malek N, Dudek B, Zeglen S, Wojarski J, Ochman M, Kucewicz E, Zembala M, Potempa J, Pyrc K. Infection with human coronavirus NL63 enhances streptococcal adherence to epithelial cells. J Gen Virol. 2011 Jun;92(Pt 6):1358-68. Epub 2011 Feb 16.
www.ncbi.nlm.nih.gov/pubmed/21325482
Guzik K, Skret J, Smagur J, Bzowska M, Gajkowska B, Scott DA, Potempa JS. Cigarette smoke-exposed neutrophils die unconventionally but are rapidly phagocytosed by macrophages. Cell Death Dis. 2011 Mar 17;2:e131.
www.ncbi.nlm.nih.gov/pubmed/21412277
Skottrup PD, Leonard P, Kaczmarek JZ, Veillard F, Enghild JJ, O'Kennedy R, Sroka A, Clausen RP, Potempa J, Riise E. Diagnostic evaluation of a nanobody with picomolar affinity toward the protease RgpB from Porphyromonas gingivalis. Anal Biochem. 2011 Aug 15;415(2):158-67. Epub 2011 Apr 20.
www.ncbi.nlm.nih.gov/pubmed/21569755
Kulig P, Kantyka T, Zabel BA, Banas M, Chyra A, Stefanska A, Tu H, Allen SJ, Handel TM, Kozik A, Potempa J, Butcher EC, Cichy J. Regulation of chemerin chemoattractant and antibacterial activity by human cysteine cathepsins. J Immunol. 2011 Aug 1;187(3):1403-10. Epub 2011 Jun 29.
www.ncbi.nlm.nih.gov/pubmed/21715684
Vincents B, Guentsch A, Kostolowska D, von Pawel-Rammingen U, Eick S, Potempa J, Abrahamson M. Cleavage of IgG1 and IgG3 by gingipain K from Porphyromonas gingivalis may compromise host defense in progressive periodontitis. FASEB J. 2011 Oct;25(10):3741-50. Epub 2011 Jul 18.
www.ncbi.nlm.nih.gov/pubmed/21768393
Pyrc K, Strzyz P, Milewska A, Golda A, Schildgen O, Potempa J. Porphyromonas gingivalis enzymes enhance infection with human metapneumovirus in vitro. J Gen Virol. 2011 Oct;92(Pt 10):2324-32. Epub 2011 Jun 29.
www.ncbi.nlm.nih.gov/pubmed/21715599
Laugisch O, Schacht M, Guentsch A, Kantyka T, Sroka A, Stennicke HR, Pfister W, Sculean A, Potempa J, Eick S. Periodontal pathogens affect the level of protease inhibitors in gingival crevicular fluid. Mol Oral Microbiol. 2012 Feb;27(1):45-56.
www.ncbi.nlm.nih.gov/pubmed/22230465
Jusko M, Potempa J, Karim AY, Ksiazek M, Riesbeck K, Garred P, Eick S, Blom AM. A metalloproteinase karilysin present in the majority of Tannerella forsythia isolates inhibits all pathways of the complement system. J Immunol. 2012 Mar 1;188(5):2338-49. Epub 2012 Jan 27.
www.ncbi.nlm.nih.gov/pubmed/22287711
Koziel J, Potempa J. Protease-armed bacteria in the skin. Cell Tissue Res. 2012 Feb 23. [Epub ahead of print]
www.ncbi.nlm.nih.gov/pubmed/22358849
Boström E.A., Ekstedt M., Kechagias S., Sjöwall C., Bokarewa M.I., Almer S. Resistin is associated with breach of tolerance and anti-nuclear antibodies in patients with hepatobiliary inflammation. Scand J Immunol. 2011 Nov;74(5):463-70.
www.ncbi.nlm.nih.gov/pubmed/21671974
Lindblad SS, Mydel P, Hellvard A, Jonsson IM, Bokarewa MI. The N-methyl-d-aspartic Acid receptor antagonist memantine ameliorates and delays the development of arthritis by enhancing regulatory T cells. Neurosignals 2012;20:61-71
www.ncbi.nlm.nih.gov/pubmed/22134197
Boström E.A, Svensson M., Andersson S., Jonsson IM., Ekwall AK., Eisler T., Dahlberg L., Smith U., Bokarewa M.I. Resistin and insulin/insulin-like growth factor signaling in rheumatoid arthritis. Arthritis Rheum. 2011 Oct;63(10):2894-904.
www.ncbi.nlm.nih.gov/pubmed/21739426