Gums & Joints

a FP7 EU collaborative project, with an aim to investigate protein citrullination as a link between periodontal disease and rheumatoid arthritis main page
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Person

Maria Bokarewa

Assistant Professor, PI
Dept. of Rheumatology and Inflammation Research
Sahlgrenska Academy at University of Gothenburg
Guldhedsgatan 10A
413 46 Goteborg, SWEDEN

E-mail: maria.bokarewa@rheuma.gu.se
    Maria Bokarewa has been a Research Fellow at University of Göteborg, Sweden, since 1998. She graduated from Moscow Medical Academy in 1986 with a degree of physician and specialised further in rheumatology. Between finishing in Moscow and starting at Göteborg she worked at the University of Paris, France, supported by the European League Against Rheumatism (EULAR) followed by 6 years at the Karolinska Institute in Stockholm doing her PhD studies at the lab of Professor Margareta Blombäck. At Göteborg, she started working in Professor Andrzej Tarkowski's group conducting research into the immunoregulation and therapy in experimental and human rheumatoid arthritis. Dr. Bokarewa became the Associated Professor in rheumatology 2004 and now established her research group with main interest in the role of proto-oncogenes in autoimmune inflammation. The research is supported by the European Commission, the Swedish Medical Research Council, the Swedish Rheumatology Association, and by the Foundation for Strategic Research. At present the group inclnudes 6 post-docs and 5 PhD students. The publication list consists of 87 original research articles ad 15 reviews. Dr.Bokarewa is a member of the working group of the Swedish Society of Rheumatology and the Swedish National Board of Health and Wealthfare evaluating the guidelines and recommendations for pharmacological treatment of rheumatoid arthritis.
  • Education:
    • 1986 Diploma of physician, First Moscow Medical Institute
    • 1998 License of physician (leg. läkare), Swedish Medical Board
    • 1991 Faculty of Medicine, Inst of Rheumatology, Moscow, Russia. Title: "Clinical features and variants of polymyalgia rheumatica", supervisors Prof. Nassonov EL, Bunchuk NV.
    • 1995 Faculty of Medicine, Karolinska Institute, Stockholm, Sweden. Title: "Phospholipid antibodies and APC resistance phenomenon in patients with thrombosis", supervisor Professor Blombäck Margareta.
    • 2001 Licence of specialist in rheumatology, Swedish Medical Board
    • 2004 April, Docentur Rheumatology, Sahlgrenska Academy at the University of Göteborg
    • Since 2004 senior rheumatologist, Sahlgrenska University Hospital/Rheumatology Clinic
    • Since year 2004 senior rheumatologist at Rheumatology Clinics, Sahlgrenska University Hospital. Special competence is treatment with immunosuppressive and biological drugs including autologous stem cell transplantation, selective T- and B-cell depletion, modulation of antigen presentation. Principal investigator in five clinical trials focused on the efficacy and safety of biological drugs in rheumatoid arthrititis and SLE, national coordinator for Sweden in three of them.
    • Attended courses on Good Clinical Practice, November 2006 and February 2007 organized by The Swedish Academy of Pharmaceutic Science
    • Since 2008 group leader, senior researcher at the Department of Rheumatology and Inflammation Research, University of Göteborg
  • Honors:
    • 1995 Triolab Coagulation Prize
    • 2000, 2003, 2004 Swedish Association of Rheumatology Prize, basic rheumatology
    • 2004 Nordic Prize in Rheumatology
  • Memberships:
    • A member of the working group of the Swedish Society of Rheumatology and the Swedish National Board of Health and Wealthfare evaluating the guidelines and recommendations for pharmacological treatment of rheumatoid arthritis
  • Editorial Board Service:
    Ad hoc referee:
    • Annals Rheumatic Diseases
    • Arthritis and Rheumatism
    • Arthritis Care and Research
    • Journal of Rheumatology
    • Rheumatology
    • Scandinavian Journal of Rheumatology
    • Inflammation Research
    • Scandinavian Journal of Immunology
    • Arthritis Research and Therapy
    • Journal of Thrombosis and Haemostasis
    • Diabetologia
    • FEBS lett
    • Microbial Pathogenesis
    • Osteoarthritis & Cartilage
    • Bone
    • Journal of Vascular Research
      • Editorial Board member of Arthritis Research and Therapy, Autoimmune Diseases.
  • Research Grants:
    Research has been supported by grants from:
    • The Medical Society of Göteborg
    • The Swedish Association against Rheumatism
    • The King Gustaf V:s 80-year Foundation
    • The Commission of European Union (FP7 Health Programme)
    • The Swedish Research Council
    • Professor Nanna Swartz Foundation
    • Ragnar och Torsten Söderberg Foundation
    • AME Wolff Foundation
    • Rune and Ulla Amlövs Trust
    • The Swedish Research Agency for Innovation Systems (VINNOVA)
    • The Swedish Foundation for Strategic Research
    • the pharmacist Hedberg's Foundation
    • Magnus Bergwall Foundation
    • The University of Göteborg
    • The Family Thölen and Kristlers Foundation
    • The Regional agreement on medical training and clinical research between the Western Götaland county council and the University of Göteborg (LUA/ALF)
  • Publications list:
    • Original publications:
      • Khan O, Jonsson IM, Ibrahim M, Andersson S, Karlsson C, Liu M, Olofsson FJ, Brisslert M, Bokarewa MI, Bergo MO. 2011. Inhibition of the geranylgeranylation of small GTPases results in hyperactivation of macrophages and spontaneous erosive arthritis in mice. J Clin Invest 121:628-39.
      • Jonsson IM, Juuti J, François P, AlMajidi R, Pietiäinen M, Lindholm C, Saller M, Driessen AJM, Kuusela P, Bokarewa M, Schrenzel J, Kontinen VP. 2010. Inactivation of the Ecs ABC transporter of Staphylococcus aureus alters transporter protein expression, susceptibility to antimicrobial agents and pathogenicity. PLoS One 5:e14209.
      • Bian L, Strzyz P, Grigorian M, Erlandsson M, Ambartsuman N, Jonsson IM, Brisslert M, Bokarewa M. 2010. Calcium-binding protein S100A4 is an essential modulator of joint destruction in staphylococcal arthritis. J Inf Dis, in press.
      • Hultgård Ekwall AK, Eisler T, Brisslert M, Bokarewa MI. 2011. The tumous associated grycoprotein podoplanin is expressed in synovial fibroblasts of the hyperplastic synovial lining layer in rheumatoid arthritis. Arth Res&Therapy, in press.
      • Hultgård Ekwall AK, Eisler T, Brisslert M, Bokarewa MI. 2011. The tumous associated grycoprotein podoplanin is expressed in synovial fibroblasts of the hyperplastic synovial lining layer in rheumatoid arthritis. Arthit Res&Ther, in press.
      • Bian L, Strzyz P, Grigorian M, Erlandsson M, Ambartsuman N, Jonsson IM, Brisslert M, Bokarewa M. 2011. Calcium-binding protein S100A4 is an essential modulator of joint destruction in staphylococcal arthritis. J Inf Dis, in press.
      • Lindblad, SS, Mydel P, Hellvard A, Jonsson IM, Bokarewa M. 2010. Inhibition of NMDA receptors ameliorates and delays development of arthritis by induction of regulatory T cells. Submitted.
      • Khan O, Jonsson IM, Ibrahim M, Andersson S, Karlsson C, Liu M, Olofsson FJ, Brisslert M, Bokarewa MI, Bergo MO. 2011. Inhibition of the geranylgeranylation of small GTPases results in hyperactivation of macrophages and spontaneous erosive arthritis in mice. J Clin Invest 121:628-39.
      • Jonsson IM, Juuti J, François P, AlMajidi R, Pietiäinen M, Lindholm C, Saller M, Driessen AJM, Kuusela P, Bokarewa M, Schrenzel J, Kontinen VP. 2010. Inactivation of the Ecs ABC transporter of Staphylococcus aureus alters transporter protein expression, susceptibility to antimicrobial agents and pathogenicity. PLoS One 5:e14209.
      • Kwiecinski J, Jin T, Josefsson E, Mitchell J, Higgins J, Tarkowski A, Foster T, Bokarewa MI. 2010. The role of the staphylokinase expression in Staphylococcus aureus triggered sepsis and septic arthritis. J Inf Dis 202:1041-9.
      • Mydel P, Wang Z, Brisslert M, Hellvard A, Dahlberg LE, Hazen SL, Bokarewa M. 2010. Carbamylation-dependent activation of T cells: a novel mechanism in the pathogenesis for autoimmune arthritis. J Immunol 184:6882-90.
      • Rehnberg M, Brisslert M, Amu S, Zendjanchi K, Hawi G, Bokarewa MI. 2010. Vaccination response to protein and carbohydrate antigens in patients with rheumatoid arthritis following rituximab treatment. Arth Res&Ther 12:R111.
      • Lindberg C, Bokarewa M. 2010. Rituximab for severe myastenia gravis - experience from five cases. Acta Neurol Scand Mar 1. [Epub ahead of print]. PMID: 20199513.
      • Magnusson M, Zendjanchi K, Lindh M, Brisslert M, Bokarewa MI. 2010. Epstein-Barr virus in the bone marrow of patients with rheumatoid arthritis predicts clinical effect of anti-CD20 treatment. Rheumatology (Oxford) 49:1911-9.
      • Verdrengh M, Bokarewa M, Ohlsson C, Stolina M, Tarkowski A. 2010. RANKL-targeted therapy inhibits bone resorption in experimental Staphylococcus aureus-induced arthritis. Bone 46:752-8.
      • Strandberg L, Verdrengh M, Amu S, Brisslert M, Bylund J, Enge M, Bokarewa M, Tarkowski A, Jansson JO. 2009. Mice chronically fed high-fat diet have increased mortality and disturbed immune response in sepsis. PLoS ONE, 4(10):e7605.
      • Svensson B, Hafström I, Forslind K, Albertsson K, Tarkowski A, Bokarewa MI. 2010. Increased expression of proto-oncogene survivin predicts joint destruction in early rheumatoid arthritis. Ann Med 42: 45-54.
      • Bian L, Josefsson E, Jonsson IM, Verdrengh M, Ohlsson C, Bokarewa M, Tarkowski A, Magnusson M. 2009. Dichloroacetate alleviates development of collagen II induced arthritis in female DBA/1 mice. Arth Res&Ther 11:R132.
      • Renhberg M, Amu S, Tarkowski A, Bokarewa MI, Brisslert M. 2009. Short and long-term effects of anti-CD20 treatment on bone marrow of patients with rheumatoid arthritis. Arth Res&Ther 11:R123.
      • Lindblad S, Mydel P, Jonsson IM, Senior R, Tarkowski A, Bokarewa M. 2009. Smoking and nicotine exposure delays development of arthritis in animal model. Arth Res&Ther 11: R88.
      • Baran M, Nilsson Möllers L, Andersson S, Jonsson IM, Bjersing J, Ekvall AK, Tarkowski A, Bokarewa MI. 2009. Survivin is an essential regulator of joint inflammation interacting with urokinase signaling. J Cell Mol Med 13:3797-808.
      • Jin T, Bokarewa MI, Amu S, Tarkowski A. 2009. Impact of therapies with biologicals on cardiovascular risk factors in rheumatoid arthritis. Clin Exp Rheumatol, 27:491-4.
      • Dehlin M, Bokarewa MI, Rottapel R, Dahlberg L, Magnusson M, Foster SJ, Tarkowski A. 2008. Intra-articular Fms-like tyrosine kinase 3 ligand expression is a driving force in induction and progression of arthritis. PLoS ONE, 3(11):e3633.
      • Boström AE, Tarkowski A, Bokarewa MI. 2009. Resistin is stored in neutrophil granules being released upon challenge with inflammatory stimuli. Biochim Biophys Acta 1793:1894-1900.
      • Larsson P, Ulfhammer E, Karlsson L, Bokarewa MI, Wåhlander K, Jern S. 2008. NF-kappaB signaling is required for IL-1beta-mediated tissue-type plasminogen activator suppression in Vascular Endothelial Cells. Thromb Res, 123:342-51.
      • Bokarewa MI, Tarkowski A, Lindh M, Dahlberg L, Magnusson M. 2008. Arthritogenic dsRNA is present in synovial fluid from rheumatoid arthritis patients with an erosive disease course. Eur J Immunol, 38:3237-44.
      • Tarkowski A, Bjersing J, Shestakov A, Bokarewa MI. 2010. Resistin competes with lipopolysaccharide for binding to TLR4. J Cell Mol Med 14:1419-31.
      • Forsblad d'Elia H, Pullerits R, Carlsten H, Bokarewa MI. 2008. The role of resistin in postmenopausal osteoporosis and hormone replacemnet treated rheumatoid arthritis patients. Rheumatology (Oxford) 47:1082-7.
      • Boström AE, Forsblad d'Elia H, Dahlgren U, Simark-Mattsson C, Hasseus B, Carlsten H, Tarkowski A, Bokarewa MI. 2008. Resistin expression is related to the intensity of inflammation in salivary gland of patients with primary Sjögren syndrome. J Rheumatol 35:2005-11.
      • Almehed K, Forsblad d'Elia H, Bokarewa MI, Carlsten H. 2008. Role of resistin as a marker of inflammation in SLE. Arth Res&Ther 30:R15.
      • Lindholm C, Börjesson-Asp K, Zendjanchi K, Sunquist AC, Tarkowski A, Bokarewa MI. 2008. Supplementation of immuno suppressive treatment with B cell depletion using anti-CD20 antibodies in refractory cases of systemic lupus erythematosus. J Rheumatol 35:826-33.
      • Osborn T, Verdengh M, Stossel TP, Tarkowski A, Bokarewa MI. 2008. Decreased circulating plasma gelsolin levels in rheumatoid arthritis. Arth Res&Ther 10:R117.
      • Jin T, Bokarewa MI, Zhu Y, Tarkowski A. 2008. Staphylokinase prevents plasmin formation by endogenous plasminogen activators. Eur J Haematol 81:8-17.
      • Mera S, Magnusson M, Tarkowski A, and Bokarewa MI. 2008. Extracellular survivin upregulates adhesion molecules on the surface of leukocytes changing their reactivity pattern. J Leuk Biol 83:149-55.
      • Galeotti L, Adrian K, Berg S, Tarkowski A, Bokarewa MI. 2008. Extracellular survivin is a marker of severe juvenile chronic arthritis. Clin Exp Rheumatol 26:373-8.
      • Bokarewa MI, Lindholm C, Zendjanchi K, Nadali M, Tarkowski A. 2007. Efficacy of anti-CD20 treatment in patients with rheumatoid arthritis resistant to MTX/TNF-alpha blockade. Scand J Immunol 66:476-83.
      • Amu S, Tarkowski A, Dörner T, Bokarewa MI, Brisslert M. 2007. The memory B cell pool contains the regulatory CD25+ B cell population. Scand J Immunol 66:77-86.
      • Nagaev I, Bokarewa MI, Tarkowski A, Smith U. 2006. Human resistin (RETN) is a myeloid-specific inflammatory cytokine with both systemic and local actions. PLoS ONE, dec.20, e.31.
      • Zare F, Magnusson M, Nilsson Möllers L, Jin T, Tarkowski A, Bokarewa MI. 2008. Arthritogenic RNA induces production of proteins belonging to fibrinolytic and coagulation cascades. J Leuk Biol 84:741-7.
      • Jonsson IM, Verdrengh M, Brisslert M, Bokarewa MI, Islander U, Carlsten H, Ohlsson C, Holmdahl R, Tarkowski A. 2007. Ethanol drinking prevents development of destructive arthritis. Proc Natl Acad Sci USA, 104:258-63.
      • Ulfhammer E, Larsson P, Karlsson L, Hrafnkelsdóttir T, Bokarewa MI, Tarkowski A, Jern S. 2006. TNF-α mediated suppression of t-PA expression in vascular endothelial cells is NF-kappaB and p38 MAPK dependent. J Thromb Haemost 4: 1781-9.
      • Pullerits R, Bokarewa MI, Dahlberg L, and Tarkowski A. 2007. Synovial fluid expression of auto-antibodies specific for RAGE predicts less erosive course of rheumatoid arthritis. Rheumatology (Oxford) 46: 1367-71.
      • Bokarewa MI, Abrahamson M, Levshin N, Egesten A, Grubb A, Dahlberg L, and Tarkowski A. 2007. Concomitant accumulation of cystatin c in the inflamed joints but decreased serum levels in patients with rheumatoid arthritis. J Rheumatol, 34:1293-301.
      • Adlesic M, Bokarewa MI, Verdrengh M, Foster S, Dahlberg L, A.Tarkowski. 2007. Histamin in patients with rheumatoid arthritis. Scand J Immunol 65:530-7.
      • Amu S, Strömberg K, Bokarewa MI, Tarkowski A, Brisslert M. 2007. CD25-expressing B lymphocytes in rheumatic diseases. Scand J Immunol 65:182-91.
      • Brisslert M, Bokarewa MI, Parsson P, Wing K, Collins LV, Tarkowski. 2006. CD25+ B-cells, a subset of human lymphocytes with distinctive phenotypic and functional properties. Immunology 117: 548-57.
      • Bokarewa MI, Hultgren O. 2005. Will interleukin-18 levels be useful for monitoring rheumatoid arthritis? Scand J Rheumatol 43:433-9
      • Pullerits R, Bokarewa M, Dahlberg L, Tarkowski A. 2005. Decreased levels of soluble Receptor for Advanced Glycation End products in patients with rheumatoid arthritis indicating deficient inflammatory control. Arth Res&Ther 7:R817-24.
      • Bokarewa MI, Dahlberg L, Tarkowski, A. 2005. Production of antibodies against tissue inhibitors of metalloproteinases (TIMP) may prevent bone destruction in patients with rheumatoid arthritis. Arth Res&Ther 7:1014-22.
      • Josefsson E, Bokarewa MI, Juuti K, Kuusela P. 2005. The surface protein Pls of methicillin-resistant Staphylococcus aueus is a virulence factor in septic arthritis. Infect Immun 73:2812-17.
      • Jin T, Bokarewa MI, Tarkowski A. 2005 The role of urokinase in immunity against Staphylococcus aureus. Microb Infect 7:1170-5.
      • Jin T, Bokarewa MI, A Tarkowski. 2005. Urokinase-type plasminogen activator, an endogenous antibiotic. J Infect Dis 192:429-37.
      • Bokarewa MI, Nagaev I, Smith U, Dahlberg L, Tarkowski A. 2005. Resistin - a new inflammatogenic cytokine participating in the pathogenesis of arthritis. J Immunol, 174: 5789-95.
      • Bokarewa MI, Lindblad S, Bokarew D, Tarkowski A. 2005. Increased expression of survivin, an anti-apoptotic protein, in synovial fluid of patients with rheumatoid arthritis. Arth Res&Ther 7:R349-R358.
      • Pullerits R, Bokarewa MI, Jonsson IM, Verdrengh M, Tarkowski A. 2005. Extracellular cytochrome c, a mitochondrial apoptosis-related protein, induces arthritis. Rheumatology (Oxford) 44:32-9.
      • Zare F, Bokarewa MI, Bergström T, Nenonen N, Flawell AR, Tarkowski A. 2004. Arthritogenic properties of double stranded (viral) RNA. J Immunol, 172: 5656-63.
      • Bokarewa MI, Tarkowski A. 2004. Human α-defensins neutralize fibrinolytic activity exerted by staphylokinase. Thromb Haemost, 91:991-9.
      • Carlsten H, Jonsson C, Bokarewa MI, Svensson L, Stålhandske T, Tarkowski A. 2004. The impact of a new immunomodulator oxo-quinoline-3-carboxamide on the progression of experimental lupus. Int Immunopharmacology, 4: 1515-23.
      • Bokarewa MI, BokarewD, Hultgren O, Tarkowski A. 2003. Decreased leptin levels in the joints of patients with rheumatoid arthritis. Ann Rheum Dis, 62:952-6.
      • Bokarewa MI, A.Tarkowski. 2003. Intra-articular instillation of infliximab for the treatment of acute joint inflammation. Ann Rheum Dis, 62: 783-4.
      • Jin T, Bokarewa MI, Foster T, Mitchell J, Higgins J, Tarkowski A. 2004. Staphylococcus aureus resists human defensins by production of staphylokinase, a novel bacterial evasion mechanism. J Immunol, 172:1169-76.
      • Pullerits R, Jonsson IM, Verdrengh M, Bokarewa MI, Andersson U, Erlandsson-Harris H, ATarkowski. 2003. High mobility group box chromosomal protein (HMGB-1) is a proinflammatory molecule inducing arthritis. Arth Rheum, 48:1693-700.
      • Jin T, Bokarewa MI, McIntyre L, Tarkowski A, Corey GR, Reller LB, VGFowler. 2003. Fatal outcome of bacteremic patients with staphylokinase deficient Staphylococcus aureus infection. J Med Microbiol 52: 919-23
      • Bokarewa MI, Jin T, A Tarkowski. 2003. Intra-articular release and accumulation of defensins and bactericidal/permeability-increasing protein in patients with rheumatoid arthritis. J Rheumatol 30: 1719-24 .
      • Jin T, TarkowskiA, Bokarewa MI. 2003. Urokinase, a constitutive component of the inflamed synovial fluid, induces arthritis. Arth. Res, 5: R9-R15 (http://arthritis-research.com/content/5/R9).
      • Bokarewa MI, Hellstrand K, A Tarkowski. 2002. Phosphorothioated oligonucleotides trigger synthesis of human coagulation serine proteinases. Thromb Haemos 88, 5, 788-94.
      • Bokarewa M, J Morrissey, A Tarkowski. 2002. Intra-articular tissue factor/factor VII complexes induce chronic arthritis. Inflam.Res 51, 471.
      • BokarewaM, J Morrissey, A Tarkowski. 2002. Tissue factor as a proinflammatory agent. Arth Res 4:190 (http://arthritis-research.com/content/4).
      • Bokarewa M, A Tarkowski. 2001. Decreased thrombin generation and mortality during S.aureus sepsis. Microbal Pathogenesis 30:247.
      • Wramsby ML, MI Bokarewa, M Blomback, AK Bremme. 2000. Response to activated protein C during normal menstrual cycle and ovarian stimulation. Hum Reprod 15:79516.
      • Shu H, M Wramsby, M Bokarewa, M Blomback, K Bremme. 2000. Decrease in protein C inhibitor activity and acquired APC resistance during normal pregnancy. J Thromb Thrombolysis 9:277.
      • Bokarewa MI, M Wramsby, K Bremme. 1998. Reactivity against phospholipids during pregnancy. Hum Reprod 13:2633.
      • Bokarewa MI, M Wramsby, K Bremme, M Blomback. 1997. Variability of the response to activated protein C during normal pregnancy. Blood Coagul Fibrinolysis 8:239.
      • Bokarewa MI, K Bremme. 1998. Production of phospholipid antibodies in selected thrombophilic women differing in genotype at the 506 site of factor V. Eur J Haematol 61:21.
      • Bokarewa MI, G Falk, K Bremme, M Blomback, B Wiman. 1997. Search for mutations in the genes of coagulation factors V and VIII with a possible predisposition to activated protein C resistance. Eur J Clin Invest 27:340.
      • Bokarewa M, Baranov A, Nasonov E, LRobert. 1996. Elastin degradation in systemic vasculitis. Pathol Biol (Paris) 44:254.
      • Bokarewa MI, K Bremme, M Blomback. 1996. Arg506-Gln mutation in factor V and risk of thrombosis during pregnancy. Br J Haematol 92:473.
      • Bokarewa MI, M Blomback, K Bremme. 1995. Phospholipid antibodies and resistance to activated protein C in women with thrombophilia. Blood Coagul Fibrinolysis 6:417.
      • Bokarewa MI, G Falk, M Sten-Linder, N Egberg, M Blomback, K Bremme. 1995. Thrombotic risk factors and oral contraception. J Lab Clin Med 126:294.
      • Bokarewa MI, K Bremme, G Falk, M Sten-Linder, N Egberg, M Blomback. 1995. Studies on phospholipid antibodies, APC-resistance and associated mutation in the coagulation factor V gene. Thromb Res 78:193.
      • Bokarewa MI, M Blomback, N Egberg, S Rosen. 1994. A new variant of interaction between phospholipid antibodies and the protein C system. Blood Coagul Fibrinolysis 5:37.
      • Bokarewa M, M Blomback. 1994. Heterogeneity of the APC-resistance phenomenon. Thromb Res 75:395.
      • Baranov AA, NP Shilkina, EL Nasonov, TB Beketova MI Bokareva, AV Prokopenko, RM Bimbazhapov, OV Gorbacheva. 1993. [The von Willebrand factor antigen in systemic vasculitis]. Ter Arkh 65:15.
      • Rytikova MI, NV Bunchuk, V Kovalev, EL Nasonov. 1993. [Cardiolipin antibodies in rheumatic polymyalgia and Horton's disease]. Klin Med 71:33.
      • Bunchuk NV, MI Rytikova. 1991. [The clinical manifestations of polymyalgia rheumatica]. Ter Arkh 63:106.
      • Bunchuk NV, Rytikova MI. 1988. Horton's disease. Revmatologiia (Mosk.) (2):56.
      • Bokarev IN, KI Khan, OA Tsvetkova, GN Detinkina, MI Rytikova. 1986. [Thrombocytic component of hemostasis in chronic nonspecific lung diseases]. Sov Med 10:20.
      • Afanas'ev Iu I, O Mikhailov, VI Nozdrin, GV Nikitenkova, MI Rytikova. 1986. [Effect of retinoic acid on the aggregation of erythrocytes and leukocytes in the blood]. Biull Eksp Biol Med 101:22.
    • Manuscripts submitted for publication:
      • Boström EA, Ekstedt M, Kechagias S, Sjöwall C, Bokarewa MI, Almer S. 2010. Resistin is elevated in autoimmune diseases of the gastrointestinal tract reflecting ANA positivity. Submitted.
      • Sobolewska E, Fraczak B, Selko K, Kosiarkiewicz A, Bokarewa M. 2010. Reactions to acetal resin implants in Wistar rats. Submitted.
      • Dehlin M, Andersson S, Erlandsson M, Brisslert M, Bokarewa M. 2010. Tyrosine kinases are essential mediators in the development of arthritis regulating maturation of dendritic cells and antigen presentation. Submitted.
      • Boström EA, Svensson M, Andersson S, Gustafsson B, Ekwall-Hultgård AK, Eisler T, Dahlberg L, Smith U, Bokarewa MI. 2010. Resistin and insulin/insulin-like growth factor signaling in rheumatoid arthritis. Arthrit Rheum, under revision.
      • Isgren A, Erlandsson M, Forslind K, Axelsson C, Andersson S, Bokarewa M. 2010. High survivin levels predict poor clinical response to infliximab treatment in patients with rheumatoid arthritis. Submitted.
    • Reviews:
      • Bokarev IN and Rytikova MI. 1986. [Haemostasis in malignancy.] Kazan Med J 10:15.
      • Bokarewa MI and Blomback M. 1997. Combination of activated protein C resistance and antibodies against phospholipids in the development of thrombosis. Semin Haematol 34:235.
      • Tarkowski A, Bokarewa MI, Collins LV, Gjertsson I, Hultgren OH, Jin T, Jonsson IM, Josefsson E, Sakiniene E, Verdrengh M. 2002. Current status of pathogenic mechanism in staphylococcal arthritis. FEMS 217:125.
      • Bokarewa MI, Jin T, Tarkowski A. 2005. Pathogens in focus. Staphylococcus aureus: Staphylokinase. Int J Biochem Cell Biol 2006, 38: 504-9.
      • Bokarewa MI and Tarkowski A. 2006. Manipulation of apoptosis as a treatment modality in rheumatoid arthritis. Future Rheumat 1:91-9.
      • Jin T, Bokarewa MI, Tarkowski A. 2007. Coagulation/fibrinolysis in arthritis and sepsis. Curr Rheum Rev, in press
      • Bokarewa MI, Tarkowski A, Magnusson M. 2007. Pathological survivin expression links viral infection with pathogenesis of erosive rheumatoid arthritis. Scan J Immunol, 66:192-8.
      • Bokarewa MI and Mydel P. 2010. Adhesion molecules in leukocytes and their reactivity. In: Modern Insights Into Disease from Molecules to Man: Adhesion molecules. Ed. VR Preedy. 2010, pp.145-164. ISBN: 978-1-57808-671-9.
      • Bokarewa MI. 2010. Vaskulitsjukdomar, primära. Internetmedicin (in Swedish).
      • Bokarewa M. 2010. Behandlingsstrategier vid tidig RA och rekommendationer vid ofullständig terapieffekt. BestPractice 2:23-31 (in Swedish).

Team members

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